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A Straightforward Synthesis of 2-[1-Alkyl-5,6-bis(alkoxycarbonyl)-1,2,3,4-tetrahydro-2-oxopyridin-3-yl]acetic Acid Derivatives via Domino Michael AdditionCyclization Reaction

✍ Scribed by Abdolali Alizadeh; Atieh Rezvanian


Book ID
112098287
Publisher
John Wiley and Sons
Year
2012
Tongue
German
Weight
154 KB
Volume
95
Category
Article
ISSN
0018-019X

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Acetal-protected (2,4-dioxocyclohex-1-yl)acetic acid derivatives were prepared by the allylation of dilithiated 1,3-cyclohexane-1,3diones, by the protection of the carbonyl groups and by the oxidation of the alkene. The products were then transformed, by amide formation and subsequent cyclization, i