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A Stochastic Model for Coupled Enzyme System

✍ Scribed by Pali Sen

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
770 KB
Volume
31
Category
Article
ISSN
0323-3847

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✦ Synopsis

The molecular biology of transformed cancer cells singles out key enzymes as senaitive targets of anti-cancefdrugs. Here we use one substrate--one intermediate-one final product model for a coupled enzyme syatcm. The transfer rates for the mechanism are taken as continuous but subject to random fluctuations. Explicit formulae for the first moments of the distribution of the process are obtained. These formulae allow us to take into account not only the variability between the subjects, but also the variability of the p r o m for a single subject. The present resulta allow ua also to build the prediction interval for a particular time period given the observations for some preceding moments.

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