The number of molecular substitutions occurring in a DNA sequence over a given time is described by a fractional-difference random walk model. This is an empirically motivated stochastic model of molecular evolution and does not address the detailed evolutionary mechanisms that lead to the substitut
A stochastic evolutionary model of molecular sequences
β Scribed by Liaofu Luo; L.E.H. Trainor
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 475 KB
- Volume
- 157
- Category
- Article
- ISSN
- 0022-5193
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β¦ Synopsis
A stochastic evolutionary model of molecular sequences is proposed. The basic forces in evolution are supposed to be mutation and selection. The concept is somewhat similar to Kauffman-Levin's concept of adaptive walks and corresponding analytical expressions have been developed. The selective force is divided into two parts: a slowly-varying part and a rapidly-changing fluctuation. The latter influences the distribution of sequences and results in an equation of motion along the flow line. The former plays a more important role in the emergence of evolutionary order. It is demonstrated that the asymmetry of selective forces would lead to a definite order of the system.
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