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A steric blockade model for inhibition of acetylcholinesterase by peripheral site ligands and substrate

✍ Scribed by Terrone L. Rosenberry; William D. Mallender; Patrick J. Thomas; Tivadar Szegletes


Book ID
114009695
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
148 KB
Volume
119-120
Category
Article
ISSN
0009-2797

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## Abstract Biphenyl‐4‐acyoxylate‐4′‐__N__‐butylcarbamates 1–8 are synthesized from 4,4′‐biphenol and are characterized as the pseudosubstrate inhibitors of acetylcholinesterase. In other words, the inhibitors bind to the enzyme and react with the enzyme to form the tetrahedral intermediates for th