A stereospecific synthesis of 2,3-disubstituted tetrahydrofuran derivatives
β Scribed by Yuekun Zhao; Roy L. Beddoes; Peter Quayle
- Book ID
- 104214371
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 273 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A stereospecific synthesis of 23-difrcncdonalised terrahydrojiuans via a rransmetallation-alhylation sequence of the corresponding 2-(tri-bwyktannyl)tetmhydrofiuans is o&r&d.
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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Single enantiomer 2,5-disubstituted-3-oxygenated tetrahydrofurans are synthesized in as little as four steps from a commercially available epoxide. The key steps are homoallylic alcohol epoxidation, palladium-catalysed alkoxy-carbonylation-lactonisation and Mitsunobu inversion. The protocol is appli
AxG2,Sdisubstitutad tetrahydrofurans, in which one of the subetituents is 3'-furany group, have been derived from trans-4(3'-furanyl)\_3-butenols 3-g by using iodine in diethyl ether in the presence of potassium carbonate at -78Β°C.