A Stereoselective Total Synthesis of Verbalactone

✍ Scribed by Biswanath Das; Keetha Laxminarayana; Martha Krishnaiah; Duddukuri Nandan Kumar

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: German
• Weight: 163 KB
• Volume: 92
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200900083

✦ Synopsis

Abstract

A stereoselective total synthesis of verbalactone has been achieved starting from commercially available hexanal. The sequence involves Maruoka allylation, diastereoselective iodine‐induced electrophillic cyclization, ring opening of epoxide, and Yamaguchi macrolactonization as the key steps.