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A stereoselective synthesis via a 5-exo-trig cyclisation of trans-2-oxohexahydro-2H-furo[3,2-b]pyrroles (pyrrolidine-trans-lactones)—potent, novel elastase inhibitors

✍ Scribed by Macdonald, Simon J. F.; Mills, Keith; Spooner, Julie E.; Upton, Richard J.; Dowle, Michael D.


Book ID
120071701
Publisher
Royal Society of Chemistry
Year
1998
Weight
202 KB
Volume
23
Category
Article
ISSN
1472-7781

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ChemInform Abstract: A Stereoselective S
✍ Simon J. F. Macdonald; Keith Mills; Julie E. Spooner; Richard J. Upton; Michael 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 2 views

A Stereoselective Synthesis via a 5-exo-trig Cyclization of trans-2-Oxohexahydro-2H-furo[3,2-b]pyrroles (Pyrrolidine-trans-lactones) -Potent, Novel Elastase Inhibitors. -With the title cyclization to (VI) as the key step, a stereoselective approach to a potent human neutrophile elastase inhibitor (