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A stereoselective synthesis of dinucleotide phosphorothioate triesters through a chiral indol-oxazaphosphorine intermediate

โœ Scribed by Jian-Chao Wang; George Just

Book ID
104256165
Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
192 KB
Volume
38
Category
Article
ISSN
0040-4039

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A stereoselective synthesis of dinucleot
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A stereoselective synthesis of dinucleotide phosphorothioates with a de of > 98%, using (S) and (R)-3-hydroxy-4-(2-indolyl)butyronitrile 3b as chiral auxiliaries, is reported. The procedure may be adaptable to solid phase synthesis.

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