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A stereocontrolled synthesis of trans-alkene isosteres of dipeptides

✍ Scribed by Andreas Spaltenstein; Philip A Carpino; Fumio Miyake; Paul B Hopkins

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
279 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

A general synthetic route to trans-alkene isosteres of protected dipeptides is reported. This sequence permits the fully stereocontrolled preparation of these isosteres in optically active form and in quantities sufficient for further biological study. Prepared in this manner were alkene isosteres of TyrAla. PhePhe. and LeuLeu.

πŸ“œ SIMILAR VOLUMES

A stereocontrolled synthesis of monofluo
A stereocontrolled synthesis of monofluoro ketomethylene dipeptide isosteres
✍ Robert V. Hoffman; Junhua Tao πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 242 KB

A simple, stel'eoc~ntrollod synthesis of monofluoro ketomethylene dipeptide isosteres has been developed. The method is short (6 sleps) and diastereoselective (85-95% de) and enantioselective (>95% ee).