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A stereocontrolled approach to (±)-nonactic acid

✍ Scribed by Yuedong Zhou; Qiongfeng Xu; Hongbin Zhai

Book ID
104095564
Publisher
Elsevier Science
Year
2008
Tongue
French
Weight
147 KB
Volume
49
Category
Article
ISSN
0040-4039

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✦ Synopsis

Racemic nonactic acid was efficiently constructed in a convergent, stereocontrolled fashion (7 steps, 27%). The present synthesis features a stereocontrolled 1,3-dione reduction with NaBH 4 /Et 2 B(OMe) and an acid-promoted stereospecific cyclization in the formation of 7.

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