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A Stem Cell-Based Approach to Cartilage Repair

✍ Scribed by Johnson, Kristen (author);Zhu, Shoutian (author);Tremblay, Matthew S. (author);Payette, Joshua N. (author);Wang, Jianing (author);Bouchez, Laure C. (author);Meeusen, Shelly (author);Althage, Alana (author);Cho, Charles Y. (author);Wu, Xu (author);Schultz, Peter G. (author)


Book ID
115441019
Publisher
American Association for the Advancement of Science
Year
2012
Tongue
English
Weight
883 KB
Volume
336
Category
Article
ISSN
0036-8075

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## Abstract To evaluate the ability of cultured mesenchymal stem cells (MSC) to repair physeal defects, MSC‐matrix constructs with 5% gelatin (group A), 10% gelatin/Gelfoam (Pharmacia, Peapack, NJ) (group B), and MSC grown in the presence of TGF‐β~3~ with Gelfoam (group C) were implanted in proxima

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## Abstract This in vivo pilot study explored the use of mesenchymal stem cell (MSC) containing tissue engineering constructs in repair of osteochondral defects. Osteochondral defects were created in the medial condyles of both knees of 16 miniature pigs. One joint received a cell/collagen tissue e