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A statistical examination of hypervariability in complementarity-determining regions of immunoglobulins

✍ Scribed by Tomoko Ohta

Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
809 KB
Volume
1
Category
Article
ISSN
1055-7903

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Two types of distributions for the frequencies of occurrence of amino acids in each position of hypervariable regions CDR-1 and CDR-2 were obtained for 2,000 immunoglobulins. The results show that some positions fit an inverse power-law distribution, while others fit an exponential-type distribution

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## Abstract The antigen binding site of an antibody is made up of residues residing in six hypervariable loops of the heavy and light chains. In most cases several or all of these loops are required for the establishment of the antigen‐binding surface. Five of these loops display a limited diversit