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A spindle cell variant of diffuse large B-cell lymphoma possesses genotypic and phenotypic markers characteristic of a germinal center B-cell origin

✍ Scribed by Carbone, Antonino; Gloghini, Annunziata; Libra, Massimo; Gasparotto, Daniela; Navolanic, Patrick M; Spina, Michele; Tirelli, Umberto


Book ID
109888364
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
409 KB
Volume
19
Category
Article
ISSN
0893-3952

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## Abstract Diffuse large B cell lymphoma (DLBCL) is an aggressive malignancy that accounts for nearly 40% of all lymphoid tumors. This heterogeneous disease can be divided into germinal center B cell‐like (GCB) and activated B cell‐like (ABC) subtypes by gene expression and immunohistochemical pro