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A specific haplotype in the 3′ end of estrogen-receptor alpha gene is associated with low bone mineral density in premenopausal women and increased risk of postmenopausal osteoporosis

✍ Scribed by B. Ongphiphadhanakul; S. Chanprasertyothin; S. Saetung; R. Rajatanavin


Publisher
Springer-Verlag
Year
2005
Tongue
English
Weight
220 KB
Volume
16
Category
Article
ISSN
0937-941X

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We examined the association of bone mineral density (BMD) with a polymorphism in the gene encoding the vitamin D receptor (VOR) that causes a change in the predicted protein sequence. The polymorphism results from a C-to-T transition and creates an initiation codon (ATG) three codons proximal to a d