A solid-phase synthetic route to substituted 7-azabenzimidazoles suitable for combinatorial library synthesis

An efficient solid phase synthetic route

An efficient solid phase synthetic route to 1,3-disubstituted 2,4(1H,3H)-Quinazolinediones suitable for combinatorial synthesis

✍ Adrian L. Smith; Christopher G. Thomson; Paul D. Leeson 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 240 KB

Novel, efficient solid phase chemistry has been developed for the synthesis of 1,3-disubstituted quinazolinediones. Anthranilic acids are linked to a chloroformate resin through the nitrogen, amines ~e coupled to the free carboxylic acid, and thermal cyclization leads to heterocycle formation and co