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A SNAP25 PROMOTER VARIANT IS ASSOCIATED WITH SCHIZOPHRENIA AND A DISTURBED SNAP25B/SNAP25A EXPRESSION RATIO IN PATIENTS

✍ Scribed by Alexandre Meary; Anne Dumaine; Pierre-Michel Llorca; Christophe Lancon; Franck Schurhoff; Andrei Szoke; Marion Leboyer; Stephane Jamain


Book ID
119365324
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
88 KB
Volume
117
Category
Article
ISSN
0920-9964

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Synaptosomal-associated protein of 25 kDa (SNAP-25) is involved in the molecular regulation of neurotransmitter release. SNAP-25 exists in two isoforms, SNAP-25a and SNAP-25b, which arise from alternate splicing and which are differentially expressed throughout the nervous system. In situ hybridizat