A slow acetylator genotype associated with an increased risk of advanced cervical cancer
✍ Scribed by Sandra Costa; Rui Medeiros; André Vasconcelos; Daniela Pinto; Carlos Lopes
- Book ID
- 106123215
- Publisher
- Springer-Verlag
- Year
- 2002
- Tongue
- English
- Weight
- 210 KB
- Volume
- 128
- Category
- Article
- ISSN
- 1432-1335
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## Abstract __N__‐acetyltransferase 2 (NAT2) is a polymorphic enzyme participating in the metabolism of numerous pharmaceutical drugs and carcinogens found in tobacco smoke and diet. The __NAT2__ gene is highly polymorphic and several different allelic variants exist that determine the acetylator p
## Abstract Glutathione S‐transferases (GSTs) are involved in detoxification of carcinogens, __e.g__., from tobacco smoke. Therefore, polymorphisms in the GST genes have been considered as potential modifiers of individual cancer risk. In a population‐based case‐cohort study where cases and the sub