Heparanase mechanisms of melanoma metast
β
Brian P. Murry; Bryan E. Blust; Amandip Singh; Timothy P. Foster; Dario Marchett
π
Article
π
2006
π
John Wiley and Sons
π
English
β 264 KB
## Abstract Heparanase (HPSEβ1) is an endoβΞ²βDβglucuronidase that cleaves heparan sulfate (HS) chains of proteoglycans (HSPG), and its expression has been associated with increased cell growth, invasion, and angiogenesis of tumors as well as with embryogenesis and tissue development. Since metastat