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A skin suction blister model in hairless rats: Application to the study of anti-inflammatory and immunomodulatory drugs

โœ Scribed by M. Rommain; C. Brossard; M.A. Piron; P. Smets


Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
464 KB
Volume
13
Category
Article
ISSN
0192-0561

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E3040, a new class of anti-inflammatory drug, was found to reduce the plasma uric acid level in the first phase of clinical studies. In the present study, the mechanism of the uricosuric action of E3040 was investigated using the hyperuricemia model rat. The fractional excretion of uric acid (FE ura