α-Methylene lactones. VII. A facile rout
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Paul A. Grieco; Kunio Hiroi
📂
Article
📅
1974
🏛
Elsevier Science
🌐
French
⚖ 190 KB
The presence of an a-methylene-y-butyrolactone is essential for cytotoxic activity3 among the sesquiterpene lactones. Recently it has been established 3c,4 that the presence of a lipophilic, conjugated ester side chain located homoallylic to the exocyclic double bond of an a-methylene-ybutyrolactone