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A site-selective solvolysis of a cyclopropylcarbinyl methanesulfonate ester: a route to oxygenated α-methylene-γ-butyrolactones

✍ Scribed by Frederick E. Ziegler; Anthony F. Marino; O.A.C. Petroff; William L. Studt


Publisher
Elsevier Science
Year
1974
Tongue
French
Weight
150 KB
Volume
15
Category
Article
ISSN
0040-4039

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α-Methylene lactones. VII. A facile rout
✍ Paul A. Grieco; Kunio Hiroi 📂 Article 📅 1974 🏛 Elsevier Science 🌐 French ⚖ 190 KB

The presence of an a-methylene-y-butyrolactone is essential for cytotoxic activity3 among the sesquiterpene lactones. Recently it has been established 3c,4 that the presence of a lipophilic, conjugated ester side chain located homoallylic to the exocyclic double bond of an a-methylene-ybutyrolactone