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A site-directed mutagenesis study on the role of isoleucine-23 of human epidermal growth factor in the receptor binding

โœ Scribed by Hiroshi Koide; Yutaka Muto; Hidefumi Kasai; Kaoru Kohri; Kumiko Hoshi; Seizo Takahashi; Ken-ichi Tsukumo; Tetsuyuki Sasaki; Takanori Oka; Tetsuo Miyake; Tohru Fuwa; Daisuke Kohda; Fuyuhiko Inagaki; Tatsuo Miyazawa; Shigeyuki Yokoyama


Book ID
113268831
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
436 KB
Volume
1120
Category
Article
ISSN
0167-4838

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Evaluation of the role of electrostatic
โœ Salil K. Niyogi; Stephen R. Campion; Douglas K. Tadaki ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 656 KB

Four residues in the carboxy-terminal domain of human epidermal growth factor (hEGF), glutamate 40, glutamine 43, arginine 45, and aspartate 46 were targeted for site-directed mutagenesis to evaluate their potential role in epidermal growth factor (EGF) receptor-ligand interaction. One or more mutat