A substitution of cytosine for thymine i
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Yuji Naritomi; Yasushi Naito; Hitoshi Nakashima; Eisuke Yokota; Takashi Imamura
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Article
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1988
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Springer
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English
⚖ 725 KB
We have described a novel human globin gene mutation that produced in a Japanese family the beta-thalassemia phenotype through a post-translational mechanism. Substitution of proline for leucine at position 110 in the G-helix of the beta-globin chain greatly reduced the molecular stability of the be