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A single-mode microwave cavity for reducing radiolabelling reaction times, demonstrated by alkylations with [11C]alkyl halides

✍ Scribed by Sharon A. Stone-Elander; Nils Elander; Jan-Olov Thorell; Gunnar Solås; Jan Svennebrink

Book ID: 102901507
Publisher: John Wiley and Sons
Year: 1994
Tongue: French
Weight: 583 KB
Volume: 34
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580341008

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✦ Synopsis

Abstract

A single‐mode microwave cavity was constructed for microscale reactions with consideration taken to the space limitations typical for shielded working spaces used with positron emitting radionuclides. The effect of the microwave field in this cavity on typical reaction media is demonstrated. Reaction times for radiolabelling neuroreceptor ligands with [^11^C]methyl iodide and [2‐^11^C]isopropyl iodide were shown to be considerably reduced compared with the times reported in the literature for the corresponding thermal procedures.

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