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A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3, and has a dominant negative effect on TGF-β signals

✍ Scribed by Daisuke Goto; Ken Yagi; Hirofumi Inoue; Itsuo Iwamoto; Masahiro Kawabata; Kohei Miyazono; Mitsuyasu Kato


Book ID
117109320
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
656 KB
Volume
430
Category
Article
ISSN
0014-5793

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## Abstract Transforming growth factor‐beta (TGF‐β) is an important growth inhibitor of epithelial cells, and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to tumorigenesis. Smad2 and Smad3 are direct mediators of TGF‐β signaling, however little is kno