A single gene difference determines relative susceptibility to caffeine-induced lethality in SWR and CBA inbred mice

A single major gene controls most of the

A single major gene controls most of the difference in susceptibility to streptozotocin-induced diabetes between C57BL/6J and C3H/HeJ mice

✍ K. Kaku; J. McGill; M. Province; M. A. Permutt 📂 Article 📅 1989 🏛 Springer 🌐 English ⚖ 971 KB

To assess genetic factors determining sensitivity to streptozotocin-induced diabetes in inbred strains of mice, a genetic analysis of streptozotocin-sensitive C57BL/6J and streptozotocin-resistant C3H/HeJ mice was performed. One week after a single dose of streptozotocin (200 mg/kg body weight), dif