Sclerostin, an osteocyte-secreted protein, negatively regulates osteoblasts and inhibits bone formation. In this first-in-human study, a sclerostin monoclonal antibody (AMG 785) was administered to healthy men and postmenopausal women. In this phase I, randomized, double-blind, placebo-controlled, a
β¦ LIBER β¦
A Single-Dose Placebo-Controlled Study of AMG 162, a Fully Human Monoclonal Antibody to RANKL, in Postmenopausal Women
β Scribed by Pirow J Bekker; Donna L Holloway; Amy S Rasmussen; Robyn Murphy; Steven W Martin; Philip T Leese; Gregory B Holmes; Colin R Dunstan; Alex M DePaoli
- Book ID
- 111485071
- Publisher
- American Society for Bone and Mineral Research
- Year
- 2004
- Tongue
- English
- Weight
- 99 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0884-0431
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Background: NI-0401 is a fully human monoclonal antibody, which binds to the CD3 subunit of the T-cell receptor, causing modulation of T-cell activity. We investigated the safety and the ability to modulate the TCR-CD3 complex of NI-0401 in patients with active Crohn's disease (CD). Methods: A doub