Testing the equality of the area under a curve (AUC) for different dose groups is frequently done in pharmacokinetic research. Equality of AUCs is one indicator of bioequivalence. When the experimental unit must be sacrificed to obtain a response, AUC can be simply estimated using a linear combinati
A simulation study comparing tests for the equality of coefficients of variation
โ Scribed by W. K. Fung; T. S. Tsang
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 136 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0277-6715
No coin nor oath required. For personal study only.
โฆ Synopsis
The coefficient of variation is commonly used in medical and biological sciences. In this paper, several parametric and non-parametric tests for the equality of coefficients of variation in k populations are reviewed. Simulation studies are conducted to compare the sizes and power of these tests. It is found that the parametric tests perform well if the data are normally distributed, but perform poorly if otherwise. The non-parametric test, however, is rather robust against the underlying distribution. An example using data of the Quality Assurance Program from the Hong Kong Medical Technology Association in Haematology and Serology is provided. The insensitivity of the non-parametric test to outliers is demonstrated.
1998 John Wiley & Sons, Ltd.
๐ SIMILAR VOLUMES
In a 2 ร 2 crossover bioavailability study, the sets of estimates of the pharmacokinetic parameters quite often have a symmetric covariance structure between the two treatments. For testing the equality of the intra-subject covariance matrices for the two treatments in such studies, we suggest in th