A simplified system for constructing recombinant adenoviral vectors containing heterologous peptides in the HI loop of their fiber knob

Generation of fiber-modified adenovirus

Generation of fiber-modified adenovirus vectors containing heterologous peptides in both the HI loop and C terminus of the fiber knob

✍ Naoya Koizumi; Hiroyuki Mizuguchi; Naoki Utoguchi; Yoshiteru Watanabe; Takao Hay 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 193 KB

## Abstract ## Background Fiber‐modified adenovirus (Ad) vectors can be effective in overcoming the limitations of conventional Ad vectors, specifically their inefficient gene transfer into cells lacking the primary receptor, the coxsackievirus and adenovirus receptor (CAR). Several types of fiber