๐”– Bobbio Scriptorium
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A simplified protocol for the mouse bone marrow micronucleus assay

โœ Scribed by Michael L. Garriott; Charles E. Piper; Andrew J. Kokkino

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
293 KB
Volume
8
Category
Article
ISSN
0260-437X

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โœฆ Synopsis

Complex and expensive protocols involving multiple sampling limes have been proposed and recommended for the in vivo mouse bone marrow micronucleus assay. The purpose of this study was to determine whether a simplified procedure employing two identical exposures and a single sampling time would be equally effective at detecting chemical clastogens. Furthermore, the utility of the protocol was investigated for both intraperitoneal and oral routes of administration. The results obtained from a group of chemicals spanning the known time range for maximum frequency of micronucleus induction prove the effectiveness of this simplified protocol.

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Assessment of 1,2-dimethylhydrazine in b
Assessment of 1,2-dimethylhydrazine in bone marrow micronucleus assay: Variations in protocol and response
โœ M. T. Goldberg; R. N. Schop; J. A. Reidy ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 684 KB

The effect of variations in experimental protocol on the assessment of the genotoxicity of 1,2dimethylhydrazine (DMH) in the bone marrow micronucleus assay was determined. The incidence of micronuclei (MN) in the bone marrow of CBA mice treated with DMH (either intraperitoneally (i.p.) or orally) wa