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A simplified procedure for synthesizing large quantities of highly purified uridine [β-32P]diphospho-N-acetylglucosamine

✍ Scribed by Les Lang; Stuart Kornefeld


Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
465 KB
Volume
140
Category
Article
ISSN
0003-2697

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✦ Synopsis


A simplified procedure for the synthesis of [beta-32P]UDP-N-acetylglucosamine is described. This novel method utilizes commercially available enzymes, chemical acetylation, and preparative thin-layer chromatography and can be used to synthesize millicurie quantities of the sugar nucleotide at an extremely high specific activity and purity.