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A simplified method to screen for in-vivo performance of oral lipid formulations

✍ Scribed by Kilic, Murat; Dressman, Jennifer

Book ID
125465802
Publisher
Pharmaceutical Press
Year
2013
Tongue
English
Weight
651 KB
Volume
66
Category
Article
ISSN
2042-7158

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Use of in vitro lipid digestion data to
Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: Studies with halofantrine
✍ Christopher J.H. Porter; Ann Marie Kaukonen; Agnes Taillardat-Bertschinger; Ben πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 196 KB πŸ‘ 1 views

The relative oral bioavailability (BA) of halofantrine base (Hf) was assessed in male beagle dogs after administration of a medium chain triglyceride (MCT), a long chain triglyceride (LCT), and a blended LCT/MCT lipid solution formulation of Hf (Study 1) and after administration of suspensions of Hf