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A simple three-component condensation: Highly efficient microwave-assisted one-pot synthesis of polyfunctional pyridine derivatives

✍ Scribed by Shujiang Tu; Dianxiang Zhou; Longji Cao; Chunmei Li; Qingqing Shao

Publisher
Journal of Heterocyclic Chemistry
Year
2009
Tongue
English
Weight
93 KB
Volume
46
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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A simple facile one‐step microwave‐enhanced synthesis of methyl 4‐substituted‐6‐amino‐5‐cyano‐2‐methylpyridine‐3‐carboxylate derivatives via a three‐component reaction of aromatic aldehydes, malononitrile, and methyl 3‐aminobut‐2‐enoate has been developed. It is an efficient and promising synthetic strategy to build the polyfunctional pyridine skeleton. J. Heterocyclic Chem., (2009)

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## Abstract magnified image In this article, efficient and simple preparation of Hantzsch pyridine derivatives by reaction of various aldehydes and β‐dicarbonyls in the presence of ammonium chlorate under solvent‐free condition at 80°C is reported. The advantages of this system are the one‐step pr