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A Simple Synthesis of 5-Spirobarbituric Acids and Transformations of Spirocyclopropanobarbiturates to 5-Substituted Barbiturates.

✍ Scribed by Palwinder Singh; Kamaldeep Paul


Book ID
101985557
Publisher
John Wiley and Sons
Year
2006
Weight
26 KB
Volume
37
Category
Article
ISSN
0931-7597

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Synthesis of 5-(functionalized acyl)-1,3
✍ Hanafi H. Zoorob; Mohamed A. Ismail; Lucjan Strekowski πŸ“‚ Article πŸ“… 2001 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 53 KB

## Abstract A sodium derivative of 1,3‐dimefhylbarbituric acid or 1,3‐diethyl‐2‐thiobarbituric acid undergoes an efficient monoacylation at C5 by the reaction with ω‐chloroalkanoyl chloride or diacid dichloride in the presence of pyridine in tetrahydrofuran. A nucleophilic displacement of the chlor