A simple route to isoindoles and related heterocycles
โ Scribed by Makhluf J. Haddadin; Nabil C. Chelhot
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- French
- Weight
- 83 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
In view of the continued interest in the chemistry of isoindoles', we report a simple one-step synthesis of isoindoles and related heterocycles. This method entails brief treatment of an ethanolic solution of a cis-2-ene-1,4-dione
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A brief, versatile synthesis of 3-dehydrosphinganine (1) and derivatives is described which features, as its key step, the reaction of diazoketones and trialkylboranes. Compatibility with chiral reagents is indicated.
The intensity of the two lines at 25 MHz remained constant over the concentration range investigated, and, since the maximum line separation is ca. 0.4 MHz, that is the magnetic environment of the two protons is very similar, significantly different relaxation effects are highly improbable. For thes