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A simple route for synthesis of 4-phospho-d-erythronate

✍ Scribed by Yehor Novikov; Shelley D. Copley; Bruce E. Eaton

Publisher: Elsevier Science
Year: 2011
Tongue: French
Weight: 164 KB
Volume: 52
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2011.02.045

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✦ Synopsis

4-Phospho-D-erythronate is an intermediate in synthesis of pyridoxal 5'-phosphate in some bacteria and an inhibitor of ribose 5-phosphate isomerase. Previous synthetic schemes for the preparation of 4-phospho-D-erythronate required expensive precursors and typically gave low yields. We report a straightforward synthesis of 4-phospho-D-erythronate from the inexpensive precursor D-erythronolactone in 5 steps with a preparatively useful yield of 22%.

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