1,4,7-Tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane is widely used as an intermediate in the preparation of medically important DO3A and DOTA metal chelators. Despite its commercial availability and importance, the literature describing the preparation and properties of the free bas
A Simple, Regioselective Synthesis of 1,4-Bis(tert-butoxycarbonylmethyl)tetraazacyclododecane.
β Scribed by Cong Li; Wing-Tak Wong
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 100 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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Aktnrlz The reaction of 1.4,7,10-tctraazd~yoModccanc with p-toluenenrlfonyl chloride in pyridinc or with diethyl phowhite and Ccl, in a water/CH&l, mixture yielda sclaotivcly the 1.7diprotcctcd regiokacr. The 1.7-dipmtected tfAraax.9 cycles are interesting Starting mstcrinls. for instana for Ihe pr