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A simple, predictive, structure-based skin permeability model

โœ Scribed by Peter Buchwald; Nicholas Bodor

Book ID
111768733
Publisher
Pharmaceutical Press
Year
2001
Tongue
English
Weight
282 KB
Volume
53
Category
Article
ISSN
2042-7158

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โœ Guoping Lian; Longjian Chen; Lujia Han ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 204 KB

A number of mathematical models have been proposed for predicting skin permeability, mostly empirical and very few are deterministic. Early empirical models use simple lipophilicity parameters. The recent trend is to use more complicated molecular structure descriptors. There has been much debate on