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A simple one-pot synthesis of 1,2,3,4-tetrahydro-2-thioxopyrimidine derivatives

✍ Scribed by Esvet Akbał; Furgan Aslanoǧlu; Ahmet Şener; Bariş Anil

Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
319 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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5‐Benzoyl‐4‐(substituted phenyl)‐6‐phenyl‐1,2,3,4‐tetrahydro‐2‐thioxopyrimidines (4a‐d) were synthesized using the Biginelli three component cyclocondensation reaction of an appropriate β‐diketone, arylaldehyde, and thiourea in acetic acid under reflux condition in approximately 52‐65% yields. The acetylation of compounds 4a‐d gave 3‐acetyl thioxopyrimidine derivatives 5a‐d. Also, pyrimidothiazine compounds 6a‐d were prepared by a simple one‐pot condensation reaction of starting pyrimidine derivatives 4a‐d and 3‐bromopropionic acid. The structures of compounds were characterized on the basis of elemental analyses, IR, ^1^H and ^13^C‐NMR spectra.

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