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A simple method of preparation of 7-alkyl-7-azabicyclo[2.2.1]heptanes

โœ Scribed by Alfred Hassner; Anatoly M. Belostotskii


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
208 KB
Volume
36
Category
Article
ISSN
0040-4039

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๐Ÿ“œ SIMILAR VOLUMES


Synthesis of 7-azabicyclo[2.2.1]heptane
โœ Elena Gรณmez-Sรฉnchez; Josรฉ Marco-Contelles ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 306 KB

## Abstract magnified image The bromination (CuBr~2~, AcOEt/CHCI~3~) plus Favorskii rearrangement (EtONa, EtOH) of __N__โ€carbethoxytropinone (**4**), readily available from tropinone (**3**), affords mixtures of __exo__โ€ and __endo__โ€isomers of 2,7โ€dicarbethoxyโ€7โ€azabicyclo[2.2.1]heptane (**1b**)

Efficient synthesis of a 7-azabicyclo[2.
โœ Hui Xiong; William Frietze; Donald W. Andisik; Glen E. Ernst; William E. Palmer; ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 610 KB

An efficient synthetic route based on generation and subsequent electrophilic reaction of a Boc-protected azabicyclo[2.2.1]heptane anion to prepare a potent GlyT1 uptake inhibitor (1) is described.