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A simple HPLC method for plasma level monitoring of mitotane and its two main metabolites in adrenocortical cancer patients

✍ Scribed by Madhu B. Garg; Jennette A. Sakoff; Stephen P. Ackland


Book ID
108161331
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
495 KB
Volume
879
Category
Article
ISSN
1873-376X

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Validation of a simple HPLC method for a
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## Abstract A simple HPLC method with ultraviolet detection has been developed and validated for the simultaneous determination of haplamine and its metabolites (__trans__/__cis__‐3,4‐dihydroxyhaplamine) in rat. A liquid–liquid extraction was used to extract the compounds from rat plasma. The analy