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A simple bis-annelation route to 3,4,5,6-tetrahydropyrido[3,2-c]quinolin-2-ones

โœ Scribed by Fredric J. Vinick; Manoj C. Desai; Stanley Jung; Peter Thadeio

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
158 KB
Volume
30
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A short, novel synthesis of the title ring system is descibed involving the intramolecular reaction of an amide dianion with a ninile followed by in siru N-alkylation of the resultant intermediate.

We recently required gram quantities of the unknown compound, 3,4,5,6_tetrahydropyrido[3,2clquinolin-2-one

(1) which was postulated to be the stucture of a major metabolite of a bioactive material.

Although N-methyl analog 2 had been prepared in two steps/l3% overall yield, it was reported that the same

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