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A simple asymmetric synthesis of 2-substituted pyrrolidines and 5-substituted pyrrolidinones

✍ Scribed by Burgess, Laurence E.; Meyers, A. I.


Book ID
115463788
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
1012 KB
Volume
57
Category
Article
ISSN
0022-3263

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Diastereoselective alkylation of N-acylnorbornene sultams 2 afforded a variety of enantiomerically pure products 3a-3e. Reduction with LiAlH 4 (LAH) followed by ditosylation furnished chiral 1,4-ditosylates 5a-5e which underwent a cyclization reaction with primary amines to afford chiral 1,3-and 1,3