A Simple and Rapid Flow-Injection Chemiluminescence Method for the Determination of Noscapine with Ru(phen)32+-Ce(IV) System
✍ Scribed by Behzad Rezaei; Ali Mokhtari; Taghi Khayamian
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 468 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0003-4592
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✦ Synopsis
Abstract
A new flow injection chemiluminescence (CL) system was used for the determination of noscapine. This technique is based on the reduction effect of noscapine on the Ru(phen)~3~^3+^, which is produced by reaction between Ru(phen)~3~^2+^ and acidic Ce(IV) solutions, and this rapid reduction produces strong CL. Calibration plots were linear over the range of 3.0×10^‐7^‐2.0×10^‐6^ mol L^‐1^ and 2.0×10^‐6^‐2.0×10^‐4^ mol L^‐1^. The CL intensity was so high, that it is able to produce a detection limit of 6.6×10^‐8^ M noscapine (3σ). The relative standard deviation of 2.0×10^‐6^ M noscapine was 1.0% (n=10). The proposed method was successfully applied for the flow injection determination of noscapine in cough and Tonin syrup samples. The results of real sample analyses show good recovery percentages (97.3‐102.4%). The minimum sampling rate was 100 samples per hour.