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A simple and rapid automated radiosynthesis of [18F]fluoroacetate

✍ Scribed by Ganghua Tang; Xiaolan Tang; Mingfang Wang; Baoyuan Li; Mingquan Liang; Quanshi Wang

Publisher
John Wiley and Sons
Year
2008
Tongue
French
Weight
214 KB
Volume
51
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Two fully automated synthetic procedures of [^18^F]fluoroacetate ([^18^F]FAC) have been developed using a modified commercial TRACERlab FX~FN~ synthesizer. One was a two‐step one‐pot procedure, consisting of nucleophilic [^18^F]fluorination of benzyl‐2‐bromoacetate as a precursor with no‐carrier‐added [^18^F]fluoride, hydrolysis within the same [^18^F]fluorination reaction vessel, and purification with/without high‐performance liquid chromatography (HPLC). The second procedure consisted of nucleophilic [^18^F]fluorination, hydrolysis on the column, and purification with SEP‐PAK cartridges instead of HPLC. The radiochemical purity of [^18^F]FAC was >95% by the two procedures. The second procedure was a simple, rapid, and fully automated synthesis of [^18^F]FAC with a high and reproducible radiochemical yield exceeding 60% (decay uncorrected) within the total synthesis time less than 20 min. The new, simple, and rapid on‐column hydrolysis procedure should be adaptable to the fully automated synthesis of [^18^F]FAC at a commercial fluoro‐deoxyglucose synthesis module. Copyright © 2008 John Wiley & Sons, Ltd.

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