A SIMPLE AND HIGHLY SENSITIVE ELISA FOR SCREENING OF THE α-THALASSEMIA-1 SOUTHEAST ASIAN-TYPE DELETION

Detection of ζ-globin chains in the cord

Detection of ζ-globin chains in the cord blood by ELISA (enzyme-linked immunosorbent assay): Rapid screening for α-thalassemia 1 (Southeast Asian type)

✍ Ausavarungnirun, Ruchanee; Winichagoon, Pranee; Fucharoen, Suthat; Epstein, Nava 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 42 KB

Fetuses with homozygous alpha-thalassemia 1, in which the deletion of all four alpha-globin genes results in the absence of any alpha-globin chains, are severely anemic with clinical features of hydrops fetalis. Definitive diagnosis of alpha-thalassemia 1 carriers is difficult since there are few re