A simple and efficient synthesis of some novel thiazolidine-4-one derivatives

✍ Scribed by Khalil Porshamsian; Naser Montazeri; Kurosh Rad-Moghadam; Safa Ali-Asgari

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2010
• Tongue: English
• Weight: 123 KB
• Volume: 47
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.458

✦ Synopsis

Abstract

magnified image Reaction of 4‐phenylthiosemicarbazide with dialkyl acetylenedicarboxylate in CH~2~Cl~2~ at 0°C lead to construction of alkyl 3‐amino‐2‐phenyliminothiazolidine‐4‐one‐5‐ylidene acetate in a few minutes and good yields. Alternatively, the use of thiosemicarbazide has given the corresponding 3‐amino‐2‐iminothiazolidine‐4‐one‐5‐ylidene acetate, while application of di‐t‐butylacetylenedicarboxylate in these reactions has not entailed with cyclization. J. Heterocyclic Chem., (2010).