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A simple and efficient synthesis of a derivatized pseudotripeptide containing a methylene thioether isostere and its use for the design of bifunctional rhenium and technetium chelating agents

✍ Scribed by Matthias Scheunemann; Bernd Johannsen

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 129 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)00083-x

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✦ Synopsis

A new approach to a pseudotripeptide based tetradentate chelating unit functionalizable with various bioactive groups has been developed. Using a one-pot reaction, a given 0)-aminoalkyl compound has been converted to a methylene thioether peptide isostere by two consecutive ring opening reactions.

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