A Simple and Efficient Access to New Functionalized 4-Phenacylideneflavenes#
β Scribed by Koneni V. Sashidhara; Abdhesh Kumar; Shikha Agarwal; Manoj Kumar; Bikash Kumar; Balasubramanian Sridhar
- Book ID
- 111992597
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 342 KB
- Volume
- 354
- Category
- Article
- ISSN
- 1615-4150
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Tetraeyclic nitrilc 19a and ester 19b , exhibiting the ABC cam of eephalotaxine la, were prepared through KI-I-i~\_\_,\_.r\_\_~\_ cyelization oΒ£ thioimides 14a and 14b, respectively. This new ring-closure methodology pt'oved to be particularly efficient: thus ~ 19a was obtained in only 7 steps with
A Simple, Efficient Access to Functionalized Pyrrolobenzazepines Related to the ABC Core of Cephalotaxine. -The new KH-induced ring closure method applied to thioimides (III) is especially efficient for the synthesis of tetracycle (IVa). It represents the ABC core of the title alkaloid and is obtai