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A Significant Role for the Heme Oxygenase-1 Gene in Endothelial Cell Cycle Progression

✍ Scribed by Taketoshi Kushida; Shuo Quan; Liming Yang; Susumu Ikehara; Attallah Kappas; Nader G. Abraham

Book ID: 115589456
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 138 KB
Volume: 291
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.2002.6403

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## Abstract The inducible protein heme oxygenase‐1 (HO‐1) catalyzes the oxidation of heme to carbon monoxide (CO) and biliverdin, which play a concerted action in cytoprotection against oxidative stress and in the modulation of cell proliferation and differentiation. Here we report that both HO‐1 e