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A side reaction encountered in using the peptide coupling reagent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ)

✍ Scribed by Joseph G. Lombardino; Susan L. Anderson; Charles P. Norris


Book ID
112125336
Publisher
Journal of Heterocyclic Chemistry
Year
1978
Tongue
English
Weight
137 KB
Volume
15
Category
Article
ISSN
0022-152X

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Use of 2-ethoxy-1-(ethoxycarbonyl)-1, 2-
✍ Myung Ho Hyun; Moon Hee Kang; Sang Cheol Han πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 223 KB

EEDQ has been utilized as a convenient reagent for the selective protection of the hydroxy group of 2hydroxycarboxylic acids. In the presence of an appropriate amine nucleophile, EEDQ has also been utilized as a reagent for the derivatization of both of the hydroxy and carboxylic acid group of 2-hyd